91̽»¨

Forschungsbereich 3: Marine Ökologie
FE Marine Naturstoffchemie

µþü°ù´Ç:
ENB, Raum: 2.423
Tel.: +49 431 600-4425
E-Mail: bmabate(at)geomar.de

Adresse:
Wischhofstraße 1-3
24148 Kiel

Research interests:

Natural (Bioproducts) valorisation 

My research focuses on the extraction, characterization, and valorisation of natural bioproducts, particularly on marine natural product chemistry. By exploring the unique chemical diversity of marine organisms, I aim to uncover bioactive compounds with applications in pharmaceuticals, nutraceuticals, cosmetics, and agriculture. My work integrates sustainable and environmentally conscious methodologies promoting the blue circular economy.

Academic positions:

Postdoctoral researcher at 91̽»¨ since January 2025

Postdoctoral researcher: Rhodes University, South Africa (May 2022-Dec 2024)

Part-time Biochemistry Lecturer: Rhodes University (Feb 2023-Dec 2024)

Selected publications

Mabate, B., Daub, C. D., Malgas, S., Pletschke, B. I (2025). Characterisation of Sargassum elegans fucoidans extracted using different technologies: linking their structure to α-glucosidase inhibition. Algal Research, 85, 103885,

Grobler, C., Mabate, B., Prins, A., Le Roes-Hill, M., Pletschke, B. I. (2024). Expression, purification, and characterisation of recombinant alginate lyase (Flammeovirga AL2) for the bioconversion of alginate into alginate oligosaccharides. Molecules, 26;29(23):5578. doi: 10.3390/molecules29235578

Mabate, B & Pletschke, B. (2023). Sequential and enzymatic extraction of Ecklonia maxima. maxima marine bioproducts for nutraceutical and pharmacological significance. Enzyme Microbial Technology, 173, 110364,

Mabate, B., Daub, C. D., Pletschke, B. I., Edkins, A. L. (2023). Comparative Analyses of Fucoidans from South African Brown Seaweeds That Inhibit Adhesion, Migration, and Long-Term Survival of Colorectal Cancer Cells. Marine Drugs, 21(4), 203;

Mabate, B.; Daub, C.D.; Malgas, S.; Edkins, A.L.; Pletschke, B.I. (2021). Combination therapy for Type 2 diabetes-related enzymes using Ecklonia radiata fucoidan and acarbose. Pharmaceutics, 13,11https://doi. org/10.3390/pharmaceutics13111979

Mabate, B.; Daub, C.D.; Malgas, S.; Edkins, A.L.; Pletschke, B.I. Fucoidan Structure. Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy. Marine Drugs, 2021, 19, 30, . org/10.3390/md19010030

Mabate, B., Daub, C.D., Malgas, S. and Pletschke, B.I. (2020). Kelp extract and their pharmaceutical properties. Atlas of Science (https: /atlasofscience.org/kelp extracts-and-their-pharmaceutical properties/more-30415)

Daub, C.D., Mabate, B., Malgas, S., Pletschke, B.I. (2020) Fucoidan from Ecklo nia maxima is a powerful inhibitor of the diabetes-related enzyme, α-glucosidase. I nternational Journal of Biological Macromolecules, 151412420, . org/10.1016/j.ijbiomac.2020.02.161.

Selected conferences

Mabate B., Daub, C. D., Edkins, A. L., Pletschke, B. I. The biological activity of bioproducts extracted from South African brown algae. International Seaweed Symposium (ISS). Tasmania, Australia (19 – 23 February 2023).

Mabate B., Daub, C. D., Edkins, A. L., Pletschke, B. I. Fucoidan, a bioproduct from brown algae, can be used in combination with acarbose to inhibit the type 2 diabetes mellitus (T2DM) related enzyme α-glucosidase. 33rd Congress of the Phycological Society of Southern Africa. The Dunes, Arniston (23 – 27 January 2023).

Mabate, B., Daub, C.D., Malgas, S., Edkins, A. L and Pletschke, B. I. Relevance of brown seaweed fucoidans as therapeutics for Type 2 diabetes mellitus (T2DM) and cancer progression. The South African Society of Biochemistry and Molecular Biology conference University of Pretoria (23-26 January 2022).